Some characteristics of ephaptic transmission of action potentials were investigated with squid giant axons. For these studies two isolated axons were placed. Thus, the secondary peaks must represent the orthodromic impulses generated by ephaptic transmission. An average inter-peak interval of ms between the. Ephaptic transmission was implied. NEUROLOGY (Ny) ; Aberrant conduction in human peripheral nerve: Ephaptic transmission? Richard A.

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Published by Elsevier Ireland Ltd. How we chose ‘justice’.

Ephaptic transmission in squid giant axons.

With incremental shifts of stimulating points distally, the latency of abnormal muscle responses increased by 0. In a preoperative study of 21 patients, we delivered a series of stimuli, in short increments, successively distally along the temporal branch of transmissioh facial nerve to record abnormal muscle responses from the orbicularis oculi and mentalis muscles.

This page was last edited on 11 Novemberat This finding implicates the antidromic motor impulse as the trigger for lateral spread. We tested the hypothesis that this anomaly results from lateral spread of impulses from one motor axon to another at the site of the nerve compression by the offending artery.

Due to the very small electrical fields produced by neurons, mathematical models are often used in order to test a number of manipulations. Dictionary Entries near ephaptic trahsmission eperythrozoonosis ephapse ephaptic ephedra ephedrine ephelis.

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Katz and Schmitt also observed that stimulation of both nerves could cause interference effects. Comments on ephaptic What made you want to look up ephaptic? The latter immediately abated, together with abnormal muscle responses, after microvascular decompression.

Retrieved from ” https: A hypothesis or explanation behind the mechanism is “one-way”, “master-slave”, or “unidirectional synchronization” effect as mathematical and fundamental property of non-linear dynamic systems oscillators like neurons to synchronize under certain criteria.

This study establishes the mechanism of lateral spread responsible for abnormal muscle responses and contributes to the understanding of pathophysiology underlying hemifacial spasm.

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Ephaptic transmission is the origin of the abnormal muscle response seen in hemifacial spasm.

Have your cake and eat pie too. The inhibition due to ephaptic coupling would help account for the integration of signals that gives rise to more nuanced perception of smells. For example, many authors have proposed models for dphaptic tissue that includes additional variables that account for the unique structure and geometry of cardiac cells [14] varying scales of size, [19] or three-dimensional electrodiffusion.

From Wikipedia, the free encyclopedia. Learn More about ephaptic.

Resources for ephaptic Time Traveler! Over time the term ephaptic coupling has come to be used not only in cases of electric interaction between adjacent elements, but also more epaptic to describe the effects induced by any field changes along the cell membrane. In the simpler case of adjacent fibers that experience simultaneous stimulation the impulse is slowed because both fibers are limited to exchange ions solely with the interstitial fluid increasing the resistance of the nerve.

Ephaptic transmission is the origin of the abnormal muscle response seen in hemifacial spasm.

In intraoperative monitoring of 10 patients during microvascular decompression, we monitored propagating nerve action potentials with a handheld electrode placed on the facial nerve 3mm distal to the vascular compression site.

Ephaptic transmission of action potentials is possible when the ephaptic region is submerged in oil, as well as when the region is immersed in low-calcium solutions.

Such phenomenon was proposed and predicted to be possible between two HR neurons, since in simulations and modeling work by Hrg. The awkward case of ‘his or her’. Some characteristics of ephaptic transmission of action potentials were investigated with squid giant axons.

For example, the currents that caused the depolarization excitation of the active nerve caused a corresponding hyperpolarization depression of the adjacent resting fiber. In Arvanitaki [5] explored the same topic and proposed the usage of the term “ephapse” from the Greek ephapsis and meaning “to touch” to describe this phenomenon and distinguish it from synaptic transmission.


Intransmiseion tests were being conducted on squid giant axons in order pehaptic find evidence of ephaptic events. Ephaptic coupling has also been found to play an important role in inhibition of neighboring neurons. Hence it is a hypothesis that neurobiology and evolution of brain coped with ways of preventing such synchronous behavior on large scale, using it rather in other special cases.

And is one way more correct than the others? Simultaneous action potential firing caused interference and resulted in decreased conduction velocitywhile slightly offset stimulation resulted in synchronization of the two impulses. Understanding the brain languageIOS Press, doi: While the idea of non-synaptic interactions between neurons has existed since the 19th transmiszion, there has historically been a lot of skepticism in the field of neuroscience.

Ephzptic nerve action potentials recorded during surgery comprised the initial antidromic signal followed by one or more additional peaks.

Studies of ephaptic coupling have also focused on its role in the synchronization and timing of action potentials in tgansmission. A similar ephaptic effect has been studied in the Mauthner cells of teleosts. Ask the Editors Word of the Year: It is concluded that in regions in which axons are confined by restricted extracellular volume, the large extracellular voltage changes arising during the passage of an action potential in one can cause ephaptic excitation in another.

This was accomplished in one study in two experimental conditions: This effect has been demonstrated and modeled in a variety of cases. This suggests that connections between the neurons still exist and work to spread signals even without traditional synapses.